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Sulfur-Directed Synthesis of Enantiopure Hydroxy 2-Sulfinyl Butadienes.

✍ Scribed by Roberto Fernandez de la Pradilla; Maria Victoria Buergo; Maria Victoria Martinez; Carlos Montero; Mariola Tortosa; Alma Viso


Publisher
John Wiley and Sons
Year
2004
Weight
265 KB
Volume
35
Category
Article
ISSN
0931-7597

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A Practical Synthesis of Enantiopure (R)
✍ Gebauer, Olaf ;BrΓΌckner, Reinhard πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 590 KB

## Abstract The title compound __R__‐4a was prepared from (–)‐quinic acid (1) in 6 steps in 18% overall yield (Scheme 3) and with 100% enantiomeric purity (Figure 1). The initiating step is the regio‐ and stereoselective acetalization of the __trans__‐oriented vicinal OH groups of 1 (+ 5 β†’ 8). Alco