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Sulfur amino acid metabolism in doxorubicin-resistant breast cancer cells

โœ Scribed by Chang Seon Ryu; Hui Chan Kwak; Kye Sook Lee; Keon Wook Kang; Soo Jin Oh; Ki Ho Lee; Hwan Mook Kim; Jin Yeul Ma; Sang Kyum Kim

Book ID
113924895
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
632 KB
Volume
255
Category
Article
ISSN
0041-008X

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## Abstract Multiple drug resistance (MDR) is a problem that seriously reduces the efficacy of many chemotherapy agents. One mechanism for MDR is increased acidification of endocytic vesicles and increased cytosol pH, so weak base chemotherapeutic agents, including doxorubicin, are trapped in endoc