✦ LIBER ✦
Sulfonated aluminium phthalocyanines as sensitizers for photochemotherapy. Effects of small light doses on localization, dye fluorescence and photosensitivity in V79 cells
✍ Scribed by Johan Moan; Kristian Berg; Helle Anholt; Kari Madslien
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- French
- Weight
- 750 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
W9 cells incubated with di-or tetrasulfonated aluminium phthalocyanines (AIPcS2 or AIPcS,) showed a granular fluorescence pattern. Co-staining with the lysosomotropic dye acridine orange (AO) indicated that the granules that were stained by these photoactive phthalocyanines were identical to lysosomes. Small light exposures made the lysosomes permeable to the dyes without inactivating the cells. Also, the lysosomal enzymes p-AGA and cathepsin (L + 6 ) were inactivated by small light