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Sulfonamide inhibition studies of the γ-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis

✍ Scribed by Vullo, Daniela; Del Prete, Sonia; Osman, Sameh M.; De Luca, Viviana; Scozzafava, Andrea; AlOthman, Zeid; Supuran, Claudiu T.; Capasso, Clemente


Book ID
122810980
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
435 KB
Volume
24
Category
Article
ISSN
0960-894X

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An inibition study of the β-carbonic anhydrase (CA, EC 4.2.1.1) DmBCA from the insect Drosophila melanogaster with sulfonamides and sulfamates is reported. Among the panel of 40 investigated compounds, the best DmBCA inhibitors were the sulfonylated benzenesulfonamides and ethoxzolamide, which showe