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Sulfated Hexasaccharides Attenuate Metastasis by Inhibition of P-selectin and Heparanase

✍ Scribed by Borsig, Lubor (author);Vlodavsky, Israel (author);Ishai-Michaeli, Rivka (author);Torri, Giangiacomo (author);Vismara, Elena (author)

Book ID
123539252
Publisher
Elsevier B.V.
Year
2011
Tongue
English
Weight
580 KB
Volume
13
Category
Article
ISSN
1522-8002

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Heparanase activity correlates with the metastatic potential of tumor cells. Moreover, the anti-metastatic effect of non-anti-coagulant species of heparin and certain sulfated polysaccharides was attributed to their heparanase-inhibiting activity. We investigated the effect of a chemically sulfated