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Sulfated cyclodextrins for the chiral separations of catecholamines and related compounds in the reversed electrophoretic polarity mode

✍ Scribed by Kyung-Hyun Gahm; Apryll M. Stalcup

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 751 KB
Volume: 8
Category: Article
ISSN: 0899-0042
DOI: 10.1002/(sici)1520-636x(1996)8:4<316::aid-chir5>3.0.co;2-d

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✦ Synopsis

The utility of negatively charged sulfated cyclodextrins (SCD) as chiral additives (CA) in capillary electrophoresis (CE) was studied in the chiral resolution of several compounds of pharmaceutical interest, including catecholamines such as norepinephrine, epinephrine, DOPA and their precursors, phenylalanine, and tyrosine. Experiments were conducted using 10 mM sodium phosphate monobasic solution and 2% SCD adjusted to pH 3.2 with phosphoric acid. Chiral recognition mechanisms were explored using structurally related analytes including basic, acidic, and neutral compounds as well as 3,5-dinitrobenzoyl phenylglycine, phenylalanine, and homophenylalanine. The advantage of the reversed electrophoretic polarity mode for the enantioresolution of these compounds is also discussed.

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