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Sulfasalazine in the treatment of juvenile chronic arthritis: A randomized, double-blind, placebo-controlled, multicenter study

✍ Scribed by Marion A. J. van Rossum; Theo J. W. Fiselier; Marcel J. A. M. Franssen; Aeilko H. Zwinderman; Rebecca ten Cate; Lisette W. A. van Suijlekom-Smit; Wilma H. J. van Luijk; Renée M. van Soesbergen; Nico M. Wulffraat; Johanna C. M. Oostveen; Wietse Kuis; Piet F. Dijkstra; Clemens F. P. van Ede; Ben A. C. Dijkmans

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
987 KB
Volume
41
Category
Article
ISSN
0004-3591

No coin nor oath required. For personal study only.

✦ Synopsis

Objective. To assess the efficacy, tolerability, and safety of sulfasalazine (SSZ) in the treatment ofjuvenile chronic arthritis (JCA).

Methods. We conducted a 24-week randomized, placebo-controlled, double-blind, multicenter study of patients with active JCA of both oligoarticular and polyarticular onset. Patients were treated with a dosage of 50 mg/kg/day of SSZ (maximum 2,000 mg/day) or placebo. The efficacy variables were joint scores, physician's, parents', and patient's overall assessments, and laboratory parameters of inflammation.

Results. Of the 69 patients enrolled, 52 (75%) completed the trial. Six patients (18%) withdrew from the placebo group, and 11 (31%) withdrew from the SSZ group (P = 0.18). In the intention-to-treat analysis of end point efficacy, between-group differences were sig-

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