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Sulfanylamide derivatives containing the 1-adamantyl group

โœ Scribed by A. I. Ivanov; M. I. Shmar'yan; A. P. Skoldinov


Book ID
112399471
Publisher
Springer
Year
1969
Tongue
English
Weight
184 KB
Volume
3
Category
Article
ISSN
0091-150X

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A new series of thiazolidine derivatives with an adamantyl group was synthesized and evaluated for their ability to inhibit 11b-hydroxysteroid dehydrogenase 1 (11b-HSD1). Our initial compound 5a showed a weak inhibitory activity. Significant improvements in potency were achieved by substituent modif