Chloroquine can no longer be recommended as the first-line treatment for falciparum malaria in several parts of Africa, given the increasing resistance of Plasmodium falcipanrm to this drug. The sulfadoxinepyrimethamine combination (SP) is obviously an alternative candidate, that has already been se
Sulfadoxine-pyrimethamine for the treatment of malaria
โ Scribed by Nicholas J. White
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 251 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0035-9203
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๐ SIMILAR VOLUMES
Artemisinin derivatives, such as artesunate, have a short half-life and very rapid anti-malarial activity. Theoretically, using such agents in conjunction with well-established anti-malarial drugs such as sulfadoxine-pyrimethamine may reduce the rate of drug resistance. Such a combination has not pr
A randomized 14-day study in vivo compared the response of Plasmodium falciparum malaria to amodiaquine (35 mg/kg) and sulfadoxine-pyrimethamine (sulfadoxine, 25 mg/kg) in symptomatic outpatients at 2 sites in northern and western Kenya during 1993. Of the 239 patients recruited, 181 (76%) completed