Suicide in later life: Some putative causes with implications for prevention

Inhibition of Flt3-activating mutations

Inhibition of Flt3-activating mutations does not prevent constitutive activation of ERK/Akt/STAT pathways in some AML cells: a possible cause for the limited effectiveness of monotherapy with small-molecule inhibitors

✍ Emilio Siendones; Nuria Barbarroja; Luis Arístides Torres; Paula Buendía; Franci 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 344 KB 👁 1 views

## Abstract The Flt3 receptor tyrosine kinase is a critical mediator in the pathogenesis of acute myeloid leukaemia (AML). Flt3‐activating mutations have been associated with poor prognosis and decreased overall survival of AML patients, thus Flt3 constitutes an ideal target for drug treatment of s