## Freedman et al. [1997: Proc Natl Acad Sci USA 94:587-592] reported linkage in nine multiplex schizophrenia families to markers on chromosome 15, using impaired neuronal inhibition to repeated auditory stimuli (P50), a neurophysiological deficit associated with schizophrenia, as the phenotype. T
Suggestive evidence for linkage of schizophrenia to markers at chromosome 15q13-14 in Taiwanese families
โ Scribed by Liu, Chih-Min ;Hwu, Hai-Gwo ;Lin, Ming-Wei ;Ou-Yang, Wen-Chen ;Lee, Sandy F.-C. ;Fann, Cathy S.J. ;Wong, Su-Hsien ;Hsieh, Shu-Hua
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 83 KB
- Volume
- 105
- Category
- Article
- ISSN
- 0148-7299
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Chromosomal region 15q11-q13 has been implicated to harbor a susceptibility gene or genes underlying autism. Evidence has been derived from the existence of cytogenetic anomalies in this region associated with autism, and the report of linkage in a modest collection of multiplex families. Most recen
Fig. 1. Nonparametric multipoint analysis of 72 families with schizophrenia/schizoaffective disorder by GENEHUNTER. a: triangles: affected females โซืกโฌ phenotype unknown, affected males โซืกโฌ affected; circles: affected males โซืกโฌ phenotype unknown, affected females โซืกโฌ affected; b: sample without 14 fe