or-anomeric uridylates, a-rug and U-rUl2, have been synthesized for the first time. These non natural a-oligoribonucleotidee strongly resist to enzymatic degradation and bind to complementary RNA strands. During the last few years, exogenous oligonucleotides binding specifically to complementary se
✦ LIBER ✦
Sugar modified oligonucleotides I. Carbo-oligodeoxynucleotides as potential antisense agents
✍ Scribed by M. Perbost; M. Lucas; C. Chavis; A. Pompon; H. Baumgartner; B. Rayner; H. Griengl; J.-L. Imbach
- Book ID
- 117058806
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 307 KB
- Volume
- 165
- Category
- Article
- ISSN
- 0006-291X
No coin nor oath required. For personal study only.
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For the first time a phosphorothioate oligoribonucleotide. namely PS-Cl4. has been synthesized on solid support. This modified oligomer is more resistant to enzymatic degradation than the corresponding rC14 and binds to complementary RNA strands. Various series of modified oligodeoxynucleotides hav