Sugar-Assisted Ligation for the Synthesis of Glycopeptides

✍ Scribed by Ashraf Brik; Chi-Huey Wong

• Book ID: 102793761
• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 791 KB
• Volume: 13
• Category: Article
• ISSN: 0947-6539
• DOI: 10.1002/chem.200700330

✦ Synopsis

Abstract

Chemical synthesis of glycoproteins from readily available materials is a powerful method for obtaining a pure product with full control of its atomic structure. Sugar‐assisted ligation (SAL) is an emerging approach that allows the synthesis of a large glycopeptide from two unprotected fragments. Contrary to other ligation methods that are limited to the use of a cysteine residue or depend on external auxiliary, SAL takes advantage of the existing sugars in glycopeptides to promote proximity between the two peptides to facilitate an amide bond formation.