Ondansetron is a highly selective antagonist at the 5-HT 3 subtype of serotonin (5-HT) receptors . The 5-HT 3 receptors are the only receptors whose effects are mediated through the ion channels rather than the G-protein series . Ondansetron has no appreciable affinity for other 5-HT receptor subtyp
Sudden gains in the treatment of generalized anxiety disorder
โ Scribed by Julie Present; Paul Crits-Christoph; Mary Beth Connolly Gibbons; Bridget Hearon; Sarah Ring-Kurtz; Matthew Worley; Robert Gallop
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 126 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0021-9762
No coin nor oath required. For personal study only.
โฆ Synopsis
Abstract
The objective of this study was to investigate the prevalence and timing of sudden gains over the course of brief, psychodynamically oriented treatment for generalized anxiety disorder (GAD). Data were used from two studies of brief (i.e., 16โsession) supportiveโexpressive psychotherapy for GAD. Anxiety symptoms were measured at every weekly treatment session. Sudden gains in anxiety symptoms were defined to parallel previous research on sudden gains in major depressive disorder (MDD). Overall, sudden gains were found for 11 of 68 participants (16.2%), with 4 (36.4%) of these patients experiencing reversals of these gains and losing over 50% of the sudden gain during subsequent treatment sessions. Applying a baseline severity cutoff and a duration criteria similar to those used in previous studies of sudden gains resulted in 10 of 29 (34.5%) patients showing sudden gains. Of these sudden gainers, 4 (40.0%) experienced a reversal and 7 (70%) experienced an upwards spike in symptoms during their psychotherapy course. When defined in a parallel fashion, rates of sudden gains in GAD are similar to those found in MDD, although anxiety symptoms are highly variable. ยฉ 2007 Wiley Periodicals, Inc. J Clin Psychol 64: 119โ126, 2008.
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