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Successful use of eculizumab in an 86-year-old patient with paroxysmal nocturnal hemoglobinuria in Japan

✍ Scribed by Ooe, Yokiko; Nagai, Tomoko


Book ID
121573769
Publisher
Springer
Year
2014
Tongue
English
Weight
233 KB
Volume
3
Category
Article
ISSN
2193-1801

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Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired hemolytic anemia caused by somatic mutations in the phosphatidylinositol glycan-complementation class A gene and the resulting absence of a key complement regulatory protein, CD59. Affected red blood cells in patients with PNH undergo int

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## Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is a debilitating and life‐threatening disease in which lysis of PNH red blood cells frequently manifests with chronic hemolysis, anemia, and thrombosis. Renal damage in PNH is associated with chronic hemosiderosis and/or microvascular thrombosi