Successful use of eculizumab in an 86-year-old patient with paroxysmal nocturnal hemoglobinuria in Japan
β Scribed by Ooe, Yokiko; Nagai, Tomoko
- Book ID
- 121573769
- Publisher
- Springer
- Year
- 2014
- Tongue
- English
- Weight
- 233 KB
- Volume
- 3
- Category
- Article
- ISSN
- 2193-1801
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Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired hemolytic anemia caused by somatic mutations in the phosphatidylinositol glycan-complementation class A gene and the resulting absence of a key complement regulatory protein, CD59. Affected red blood cells in patients with PNH undergo int
## Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is a debilitating and lifeβthreatening disease in which lysis of PNH red blood cells frequently manifests with chronic hemolysis, anemia, and thrombosis. Renal damage in PNH is associated with chronic hemosiderosis and/or microvascular thrombosi