## Abstract ## Objective Recurrent digital ulcers are a manifestation of vascular disease in patients with systemic sclerosis (SSc; scleroderma) and lead to pain, impaired function, and tissue loss. We investigated whether treatment with the endothelin receptor antagonist, bosentan, decreased the
✦ LIBER ✦
Successful treatment of systemic sclerosis-related digital ulcers and sarcoidosis with endothelin receptor antagonist (bosentan) therapy
✍ Scribed by J. Tillon; F. Hervé; D. Chevallier; J-F. Muir; H. Levesque; I. Marie
- Book ID
- 108668751
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 560 KB
- Volume
- 154
- Category
- Article
- ISSN
- 0007-0963
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## Abstract ## Objective Increased endothelin activity may play a role in the pathogenesis of vascular injury, a primary feature of systemic sclerosis (SSc; scleroderma). Our goal was to test the hypothesis that treatment with the oral endothelin receptor antagonist bosentan might improve vascular