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Successful treatment of SAPHO syndrome with zoledronic acid

✍ Scribed by Petros Kopterides; Dimitrios Pikazis; Christos Koufos

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
78 KB
Volume
50
Category
Article
ISSN
0004-3591

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✦ Synopsis

Abstract

The SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a chronic, relapsing, inflammatory condition with skin and osteoarticular manifestations. Its etiology remains unclear, and various treatment regimens with steroids and nonsteroidal antiinflammatory drugs frequently fail to control the disease, while exposing patients to the side effects of these drugs. Because the SAPHO syndrome manifests as a destructive inflammatory bone disease, use of bisphosphonates that possess antiosteoclastic and probably antiinflammatory properties has been suggested to be helpful. To our knowledge, this is the first reported case of successful treatment with zoledronic acid of SAPHO syndrome that was resistant to conventional treatment.

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