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Successful treatment of MuSK antibody–positive myasthenia gravis with rituximab

✍ Scribed by Berit Hain; Karin Jordan; Marcus Deschauer; Stephan Zierz

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 91 KB
Volume: 33
Category: Article
ISSN: 0148-639X
DOI: 10.1002/mus.20479

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✦ Synopsis

Abstract

We report on a 56‐year‐old woman with muscle‐specific receptor tyrosine kinase (MuSK) antibody–positive myasthenia with predominant bulbar symptoms and respiratory insufficiency. Conventional immunosuppression (prednisolone, azathioprine, mycophenolate mofetil) could not maintain the clinical improvement initially achieved by repeated plasma exchanges. Therefore, treatment with rituximab was initiated. After 2 months of rituximab treatment, remarkable clinical improvement correlating with a reduction of MuSK serum antibodies was seen. The patient continued to remain remain stable 12 months after initiation of therapy. This case report demonstrates that rituximab may be an effective and tolerable treatment in MuSK antibody–positive myasthenia gravis. Muscle Nerve, 2005

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