Successful treatment of invasive aspergillosis complicating prolonged treatment-related neutropenia in acute myelogenous leukemia with amphotericin B lipid complex

✍ Scribed by Hospenthal, Duane R. ;Byrd, John C. ;Weiss, Raymond B.

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 365 KB
• Volume: 25
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/mpo.2950250214

✦ Synopsis

Abstract

Herein we report the successful treatment of invasive aspergillosis with the liposomal amphotericin B (AMB) formulation, Amphotericin B Lipid Complex (ABLC™). This investigational compound was employed in a 50‐year‐old patient with acute myelomonocytic leukemia complicated by prolonged, treatment‐induced granulocytopenia and documented Aspergillus flavus sinusitis with signs of disseminated aspergillosis. The patient demonstrated radiographic signs of pulmonary aspergillosis and biochemical signs of hepatic involvement that were resistant to a 23 day course of conventional AMB (Fungizone®) therapy. Following therapy with ABLC™ her fever abated, her chest X‐ray findings improved, and her hepatic function tests improved with eventual resolution. © 1995 Wiley‐Liss, Inc.