Successful therapy and regression of splenomegaly in a patient with myeloproliferative hypereosinophilic syndrome (MHES) treated with imatinib
β Scribed by Ridz, S.L.; Khan, D.A.
- Book ID
- 119275727
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 25 KB
- Volume
- 115
- Category
- Article
- ISSN
- 1097-6825
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## Abstract ## BACKGROUND Imatinib mesylate is a selective tyrosine kinase inhibitor of cβabl, bcr/abl, cβkit, and plateletβderived growth factorβreceptor (PDGFβR). cβkit is expressed in most patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) and PDGF has been implicated
## Abstract Hypereosinophilic syndrome (HES) is a rare disorder characterized by persistent and marked eosinophilia, leading to endβorgan damage. Over the last decade, great progress has been made in unraveling the molecular basis of HES that has resulted in the characterization of specific genetic