Successful therapeutic plasma exchange in a 3.2-kg body weight neonate with atypical hemolytic uremic syndrome

✍ Scribed by Sunkyung Jung; Eun-Suk Kang; Chang-Seok Ki; Dae-Won Kim; Kyung-Hoon Paik; Yun Sil Chang

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 151 KB
• Volume: 26
• Category: Article
• ISSN: 0733-2459
• DOI: 10.1002/jca.20283

✦ Synopsis

Abstract

Atypical hemolytic uremic syndrome (aHUS) is a rare form of complement dysregulation disease, and recently various reports have shown that it is associated with one or more mutations in the complement regulatory genes including complement factor H (CFH). Plasma exchange is a therapeutic option for adult patients, but not for a very young infant because of a potential side effect of therapeutic plasma exchange (TPE) itself. Herein, we describe a case of successful treatment of early onset aHUS associated with a novel CFH mutation with total 21 sessions of TPE over a period of 46 days in 3.2 kg 23‐day‐old neonate. J. Clin. Apheresis, 2011. © 2011 Wiley‐Liss, Inc.