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Successful remission induction by low-dose all-trans retinoic acid alone in a patient with acute promyelocytic leukemia and renal impairment

✍ Scribed by Kengo Matsumoto; Hiroya Tamaki; Tamotsu Yamagami; Noriaki Sasaki; Shuuji Hara; Toshihiro Soma


Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
172 KB
Volume
32
Category
Article
ISSN
0145-2126

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Background. Differentiation therapy with all-trans retinoic acid (RA) induces more than 80% complete remission with the least complications in patients with acute promyelocytic leukemia (APL). The authors studied the cost-benefit of this new treatment modality compared with conventional chemotherapy

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## Abstract The use of arsenic trioxide (As~2~O~3~, ATO) combined with all‐trans retinoic acid (ATRA) has recently been reported to induce remission in patients with acute promyelocytic leukemia (APL). However, its efficiency remains inconclusive mainly due to the small number of the available case