Successful reduced intensity allogeneic stem cell transplantation for systemic AL amyloidosis

✍ Scribed by Tomoyuki Imamura; Masao Ogata; Kazuhiro Kohno; Tadashi Tomo; Eiichi Ohtsuka; Hiroshi Kikuchi; Jun-ichi Kadota

• Book ID: 101437414
• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 86 KB
• Volume: 81
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/ajh.20544

✦ Synopsis

Abstract

No established treatments for systemic AL amyloidosis have been determined, and only four reports have described allogeneic stem cell transplantation for this disease. We report the case of a patient with orthostatic hypotension, diarrhea, nephrotic syndrome, and cardiac amyloidosis due to systemic AL amyloidosis. Reduced intensity allogeneic stem cell transplantation (RIST) was performed using a conditioning regimen comprising fludarabine 125 mg/m^2^ and melphalan 90 mg/m^2^. Hematologically complete remission and symptomatic improvement were obtained without severe transplantation‐related complications. RIST may thus offer a useful treatment strategy for systemic AL amyloidosis complicated by cardiac amyloidosis. Am. J. Hematol. 81:281–283, 2006. © 2006 Wiley‐Liss, Inc.