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Successful methylphenidate treatment of early onset extreme obesity in a child with a melanocortin-4 receptor gene mutation and attention deficit/hyperactivity disorder

✍ Scribed by Özgür Albayrak; Beate Albrecht; Susann Scherag; Nikolaus Barth; Anke Hinney; Johannes Hebebrand

Book ID: 113589162
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 253 KB
Volume: 660
Category: Article
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2010.12.023

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## Abstract Several lines of evidence indicate an involvement of brain derived neurotrophic factor (BDNF) in body weight regulation and activity: heterozygous __Bdnf__ knockout mice (__Bdnf__^+/−^) are hyperphagic, obese, and hyperactive; furthermore, central infusion of BDNF leads to severe, dose‐