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Successful in utero gene transfer using a gene gun in midgestational mouse fetuses

✍ Scribed by Jyoji Yoshizawa; Xiano-Kand Li; Masayuki Fujino; Hiromitu Kimura; Ryoji Mizuno; Akihiko Hara; Syuichi Ashizuka; Masaki Kanai; Naruo Kuwashima; Masashi Kurobe; Yoji Yamazaki

Book ID: 116684308
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 149 KB
Volume: 39
Category: Article
ISSN: 0022-3468
DOI: 10.1016/j.jpedsurg.2003.09.001

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## Abstract Summary: This study describes an in utero approach for overexpressing genes in a cell‐type directed manner. It uses an avian leukosis retroviral expression system coupled with a transgenic mouse line expressing the viral receptor __tv‐a__ from a tissue‐specific promoter (RCAS‐TVA system