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Successful adoptive immunotherapy with OK432-inducible activated natural killer cells in tumor-bearing mice

✍ Scribed by Hiroki Yamaue; Hiroshi Tanimura; Makoto Iwahashi; Takuya Tsunoda; Masaji Tani; Masaya Inoue

Publisher
Springer
Year
1990
Tongue
English
Weight
817 KB
Volume
2
Category
Article
ISSN
0921-299X

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The natural-killer(NK)-cell-mediated cytotoxicity to syngeneic tumor cells can be augmented by in vivo priming and subsequent in vitro challenge with the streptococcal preparation OK432. Supernatants of cocultures of spleen cells with OK432 contained interleukin-2 (IL-2) and interferon (IFN), mainly