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Subunit-specific inhibition of inward-rectifier K+ channels by quinidine

✍ Scribed by T. Doi; B. Fakler; J.H. Schultz; H. Ehmke; U. Brändle; H.-P. Zenner; H. Süßbrich; F. Lang; J.P. Ruppersberg; A.E. Busch

Book ID
115931515
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
408 KB
Volume
375
Category
Article
ISSN
0014-5793

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Hypercapnia has been shown to affect cellular excitability by modulating K(+) channels. To understand the mechanisms for this modulation, four cloned K(+) channels were studied by expressing them in Xenopus oocytes. Exposures of the oocytes to CO(2) for 4-6 min produced reversible and concentration-