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Subtype Selective NMDA Receptor Antagonists: Evaluation of Some Novel Alkynyl Analogues.

โœ Scribed by Brian E. Kornberg; Sham S. Nikam; Jon L. Wright; Suzanne R. Kesten; Leonard T. Meltzer; Linda Coughenour; Bridget Barr; Kevin A. Serpa; Julie McCormick


Publisher
John Wiley and Sons
Year
2004
Weight
81 KB
Volume
35
Category
Article
ISSN
0931-7597

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## Abstract [2โ€(3,4โ€Dihydroโ€1Hโ€isoquinolinโ€2โ€yl)โ€pyridinโ€4โ€yl]โ€dimethylamine, Roโ€647312 (**1**) represents a new novel class of NR1/2B subtype selective NMDA ligand. Roโ€647312 has been radiolabelled with carbonโ€11 using [^11^C]methyl triflate from the __norโ€__methyl compound **2**. The reaction was