Type I procollagen in the severe non-let
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Ruggero Tenni; Giuseppe Cetta; Katharine Dyne; Antonio Rossi; Daniela Quacci; Lu
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Article
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1988
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Springer
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English
β 727 KB
We have screened type I procollagen synthesized in vitro by skin fibroblasts from several patients with the severe non-lethal form of osteogenesis imperfecta. Cells from one patient synthesized and secreted both normal and a larger amount of abnormal type I procollagen. The abnormal alpha chains are