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Subtle genomic alterations and genomic instability revealed in diploid cancer cell lines

✍ Scribed by Xueying Mao; Bryan D. Young; Tracy Chaplin; Janet Shipley; Yong-Jie Lu


Book ID
116334740
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
443 KB
Volume
267
Category
Article
ISSN
0304-3835

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## Abstract Genomic alterations influencing the expression and/or activity of tumor suppressors or oncogenes such as __KRAS2__, __CDKN2A__, __TP53,__ and __DPC4__ have been directly implicated in the initiation and progression of human pancreatic adenocarcinoma. In an effort further to systematical