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Subthalamic-thalamic DBS in a case with spinocerebellar ataxia type 2 and severe tremor—A unusual clinical benefit

✍ Scribed by Hans-Joachim Freund; Utako B. Barnikol; Dagmar Nolte; Harald Treuer; Georg Auburger; Peter A. Tass; Madjid Samii; Volker Sturm

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
210 KB
Volume
22
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

This is a single case report of a patient with spinocerebellar ataxia type 2 (SCA2) and severe tremor. Whereas disease progression with prevailing ataxia and dysmetria was slow over the first symptomatic 6 years, 6 months prior to operation were characterized by the development of a severe, debilitating postural tremor rendering the patient unable to independently sit, stand, speak, or swallow. Deep brain stimulation (DBS) at a subthalamic–thalamic electrode position almost completely arrested her tremor. The patient regained the functional state prior to her rapid disease progression allowing a restricted range of daily activities. Her condition has remained approximately stable over the two postoperative years to date. In addition to the efficacy of DBS on cerebellar tremor, the results illustrate a remarkable improvement of the patient's general condition and independence.

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