✦ LIBER ✦

Subthalamic nucleus stimulation for Parkinson's disease preferentially improves akinesia of proximal arm movements compared to finger movements

✍ Scribed by Roland Wenzelburger; Florian Kopper; Bao-Rong Zhang; Karsten Witt; Wolfgang Hamel; Dieter Weinert; Johann Kuhtz-Buschbeck; Mukaddes Gölge; Michael Illert; Günther Deuschl; Paul Krack

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 182 KB
Volume: 18
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.10501

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✦ Synopsis

Abstract

Deep brain stimulation of the subthalamic nucleus (STN‐DBS) reduces akinesia in Parkinson's disease but its impact on fine motor functions was unknown. We assessed the effects of DBS and a levodopa (L‐dopa) test on the timing of the precision grip in 18 patients. Improvement on UPDRS‐items reflecting hand functions and the shortening of the first phases of the precision grip were more distinct in the L‐dopa test than in the pure STN‐DBS condition. Other akinesia items and the time for build‐up of lifting force were equally improved in both conditions. This suggests that routine STN‐DBS might not be equally effective on all aspects of fine motor functions. © 2003 Movement Disorder Society

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## Abstract Five parkinsonian subjects with chronic bilateral stimulation of the subthalamic nucleus and five sex‐ and age‐matched healthy controls grasped, lifted, and held an instrumented object. The grip–lift task was either performed at self‐determined speed or in response to an auditory cuing