## Communicated by Ulf Landegren Subtelomeric rearrangements are responsible for 5% to 10% of cases of unexplained mental retardation. Despite their clinical relevance, methods to screen for these cytogenetically invisible abnormalities on a routine base are scarce. We screened patients with idiopa
Subtelomeric rearrangements detected in patients with idiopathic mental retardation
✍ Scribed by Anderlid, Britt-Marie ;Schoumans, Jacqueline ;Annerén, Göran ;Sahlén, Sigrid ;Kyllerman, Mårten ;Vujic, Mihailo ;Hagberg, Bengt ;Blennow, Elisabeth ;Nordenskjöld, Magnus
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 562 KB
- Volume
- 107
- Category
- Article
- ISSN
- 0148-7299
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In recent years, subtelomeric rearrangements, e.g., chromosome deletions or duplications too small to be detected by conventional cytogenetic analysis, have emerged as a significant cause of both idiopathic and familial mental retardation. As mental retardation is a common disorder, many patients ne
## Abstract Microdeletions, either subtelomeric or interstitial, are responsible for the mental handicap in approximately 10–20% of all patients. Currently, Multiplex Ligation‐dependent Probe Amplification (MLPA) is widely used to detect these small aberrations in a routine fashion. Although cost‐e