Substratification of high-risk localised prostate cancer treated by radical prostatectomy
✍ Scribed by Michele Lodde; François Harel; Louis Lacombe; Yves Fradet
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 268 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0724-4983
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The clinical course of prostate cancer is highly variable and cannot satisfactorily be predicted by histological criteria alone. Both tumour cell proliferation and neuroendocrine differentiation have been suggested as additional prognostic parameters, neuroendocrine differentiation being considered
## BACKGROUND. The routine use of serum prostate-specific antigen (PSA) testing combined with digital rectal examination has lowered tumor volume and clinical-pathological stage of men undergoing radical prostatectomy. Therefore, we may identify more men with poorly differentiated tumors of early