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Substrates of human hepatic cytochrome P450 3A4

✍ Scribed by Albert P. Li; Donald L. Kaminski; Asenath Rasmussen

Book ID
107939014
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
572 KB
Volume
104
Category
Article
ISSN
0300-483X

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## Abstract Significant changes in drug‐metabolizing enzyme (DME) expression occur during ontogeny. Such changes can have a profound effect on therapeutic efficacy in the fetus and child, as well as the risk for adverse drug reactions. To gain a better understanding of DME ontogeny, enzyme contents