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Substrate/propeptide-derived endo-epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors

✍ Scribed by Norbert Schaschke; Irmgard Assfalg-Machleidt; Werner Machleidt; Luis Moroder


Book ID
117108611
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
77 KB
Volume
421
Category
Article
ISSN
0014-5793

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Novel Peptidyl Aryl Vinyl Sulfones as Hi
✍ Laura Mendieta; Anna Picó; Teresa Tarragó; Meritxell Teixidó; Marcos Castillo; L 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 995 KB

## Abstract __Herein we present the design, synthesis, and evaluation of a structurally novel library of 20 peptidyl 3‐aryl vinyl sulfones as inhibitors of cathepsins L and B. The building blocks, described here for the first time, were synthesized in a highly efficient and enantioselective manner,