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Substrate Specificity of the Human Protein Phosphatase 2Cδ, Wip1 †

✍ Scribed by Yamaguchi, Hiroshi; Minopoli, Giuseppina; Demidov, Oleg N.; Chatterjee, Deb K.; Anderson, Carl W.; Durell, Stewart R.; Appella, Ettore


Book ID
126465523
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
627 KB
Volume
44
Category
Article
ISSN
0006-2960

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## Abstract The substrate specificity of catalytic domains and the activation of full length protein tyrosine phosphatases, SHP‐1 and SHP‐2 have been investigated using synthetic phosphotyrosyl peptides derived from SIPRα1. We found that the catalytic domains of SHP‐1 and SHP‐2 exhibit different su