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Substrate specificity of the acyl transferase domains of EpoC from the epothilone polyketide synthase

✍ Scribed by Petković, Hrvoje ;Sandmann, Axel ;Challis, Iain R. ;Hecht, Hans-Jürgen ;Silakowski, Barbara ;Low, Lindsey ;Beeston, Nicola ;Kuščer, Enej ;Garcia-Bernardo, Jose ;Leadlay, Peter F. ;Kendrew, Steven G. ;Wilkinson, Barrie ;Müller, Rolf


Book ID
118042441
Publisher
Royal Society of Chemistry
Year
2008
Tongue
English
Weight
390 KB
Volume
6
Category
Article
ISSN
1477-0520

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## Background: Polyketides are important compounds with antibiotic and anticancer activities. several modular polyketide synthases (pkss) contain a terminal thioesterase (te) domain probably responsible for the release and concomitant cyclization of the fully processed polyketide chain. because the