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Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver

✍ Scribed by P J Meier; U Eckhardt; A Schroeder; B Hagenbuch; B Stieger

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 295 KB
Volume: 26
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.510260641

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✦ Synopsis

The Na+-dependent bile salt uptake systems Ntcp (rodents) and NTCP (human), and the Na+-independent organic anion transporters oatpl (rat) and OATP (human) mediate sinusoidal uptake of a variety of amphipathic organic compounds into hepatocytes. Their properties indicate that an overall hepatic clearance of albumin-bound compounds is mediated by a limited number of multispecific transporters with partially overlapping substrate specificities.

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