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Substrate specificity of manganese-activated prolidase in control and prolidase-deficient cultured skin fibroblasts

โœ Scribed by J. Butterworth; D. Priestman


Publisher
Springer
Year
1984
Tongue
English
Weight
363 KB
Volume
7
Category
Article
ISSN
0141-8955

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Cultured skin fibroblasts from controls and patients with lysosomal storage diseases were loaded with GM1 ganglioside that had been labelled with tritium in its ceramide moiety. After a 65-h or 240-h incubation, a large percentage of this ganglioside remained undegraded in GM1 gangliosidoses, wherea