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Substrate Specificity of Cathepsins D and E Determined by N-Terminal and C-terminal Sequencing of Peptide Pools

✍ Scribed by Danièle Arnold; Wieland Keilholz; Hansjörg Schild; Tilman Dumrese; Stefan Stevanović; Hans-Georg Rammensee

Book ID
115133779
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
995 KB
Volume
249
Category
Article
ISSN
1432-1327

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A method has been developed to determine preferred residue substitutions in the P' position of peptide substrates for proteolytic enzymes. The method has been validated with four different enzymes; the angiotensin I-converting enzyme, atrial dipeptidyl carboxyhydrolase, bacterial dipeptidyl carboxyh