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Substrate specificity of 3-methyladenine-DNA glycosylase from calf thymus

✍ Scribed by Rune MALE; Bjørn Ivar HAUKANES; Dag E. HELLAND; Kjell KLEPPE

Book ID
115125096
Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
801 KB
Volume
165
Category
Article
ISSN
1432-1327

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Damage to DNA can result in strand breaks with 58-hydroxyl and 38-phosphate termini. Before DNA polymerases and ligases can rejoin the broken strands, such termini have to be restored to 58-phosphate and 38-hydroxyl groups. Polydeoxynucleotide kinase is an enzyme that may fulfil this function. We ha