Substrate selective inclusion by a series of water-soluble paracyclophanes — host-guest recognition of steric structure and charge —

✍ Scribed by Kazunori Odashima; Tsunehiko Soga; Kenji Koga

• Publisher: Elsevier Science
• Year: 1981
• Tongue: French
• Weight: 272 KB
• Volume: 22
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)92489-x

✦ Synopsis

Substrate selective complex formation was observed between a series of watersolubleacyclophanes (l_a,b,z) and organic guests in acidic aqueous solutions, and this selectivity was shown to be based upon the host-guest recognition of steric structure and charge. Substrate selective inclusion by host molecules such as enzymes, antibodies and receptors, which is the initial step in many important biological reactions, is one of the significant bases for the extremely high efficiencies that are widely observed in these reactions. Considering that the selectivity in substrate inclusion is mainly based upon the well-defined structure of the inclusion cavities of these biological host molecules,' it is worthwhile to