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Substrate inhibitors and blockers of excitatory amino acid transporters in the treatment of neurodegeneration: critical considerations

✍ Scribed by Tiziana Mennini; Elena Fumagalli; Marco Gobbi; Caterina Fattorusso; Bruno Catalanotti; Giuseppe Campiani


Book ID
113584269
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
280 KB
Volume
479
Category
Article
ISSN
0014-2999

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## Abstract Glutamate is an essential excitatory neurotransmitter regulating brain functions. Excitatory amino acid transporter (EAAT)‐2 is one of the major glutamate transporters expressed predominantly in astroglial cells and is responsible for 90% of total glutamate uptake. Glutamate transporter