✦ LIBER ✦
Substrate-charge dependence of stoichiometry shows membrane potential is the driving force for proton-peptide cotransport in rat renal cortex
✍ Scribed by C. S. Temple; J. R. Bronk; P. D. Bailey; C. A. R. Boyd
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 506 KB
- Volume
- 430
- Category
- Article
- ISSN
- 0031-6768
No coin nor oath required. For personal study only.
✦ Synopsis
The proton dependence of the transport of three labelled, hydrolysis-resistant synthetic dipeptides carrying a net charge of -1, 0 or + 1 has been investigated in a brush border membrane vesicle preparation obtained from rat renal cortex. Cross-inhibition studies are consistent with the transport of all peptides studied being through a single system. The extent and time course of uptake in response to an inwardly directed electrochemical gradient of protons differed for each peptide.