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Substrate alterations in a sarcoma-bearing rat model: Effect of tumor growth and resection

✍ Scribed by H.Richard Alexander; Patrick DePippo; Sanjay Rao; Michael E. Burt

Book ID
116010524
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
587 KB
Volume
48
Category
Article
ISSN
0022-4804

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## Abstract Schedule dependent inhibition of thymidylate synthase (TS) and tumor growth by 5‐fluorouracil (FUra) was examined in Yoshida sarcoma (YS) bearing Donryu rats. After implantation of YS cells (1 Γ— 10^4^), FUra (20 mg/kg/day) was continuously (group C) or daily bolus injection (group B) ad