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Substratbedingte Nachbargruppeneffekte als bestimmende Faktoren bei der enzymatischen Hydrolyse I. Neue Befunde an der Serum-Cholinesterase

✍ Scribed by Elsbeth Schätzle; Max Rottenberg

Publisher: John Wiley and Sons
Year: 1962
Tongue: German
Weight: 327 KB
Volume: 45
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19620450329

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✦ Synopsis

Abstract

Comparative rate studies are presented on the choline‐esterasecatalyzed hydrolysis of selected synthetic substrates. Taken in conjunction with previous work on non‐enzymatic hydrolysis, the present results provide new evidence that factors other than molecular shape are essential in determining substrate specificities, one important feature being the availability, on the substrate level, of pathways involving anchimeric participation of neighbouring groups during nucleophilic attack on the ester carbonyl. It is suggested that nucleophilic catalysis is a rate determining step in choline‐esterasecatalyzed hydrolysis.

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✍ Ernst Wenger; Hans Urheim; Max Rottenberg 📂 Article 📅 1962 🏛 John Wiley and Sons 🌐 German ⚖ 362 KB

## Abstract Kinetic evidence is presented to demonstrate that α‐acylamino esters and N‐acyl‐dipeptide esters exhibit unusually high reactivities toward neutral and alkaline hydrolysis. The authors infer that the same must be true for other typical chymotrypsin substrates such as dipeptide amides, h