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Substitution of the 2′-Hydroxyl Group at Position 2.1 by an Amino Group Interferes with Mg2+ Binding and Efficient Cleavage by Hammerhead Ribozyme

✍ Scribed by Mouldy Sioud; Marianne Leirdal

Book ID
115584336
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
246 KB
Volume
262
Category
Article
ISSN
0006-291X

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✍ Ermond van Beek; Clemens Löwik; Ivo Que; Socrates Papapoulos 📂 Article 📅 2009 🏛 American Society for Bone and Mineral Research 🌐 English ⚖ 522 KB

## Abstract The purpose of this study was to examine the role of the R~1~ moiety of bisphosphonates in binding to bone mineral and for antiresorptive action. For this, the R~1~ chain of three clinically useful hydroxybisphosphonates (etidronate, pamidronate, and olpadronate) was substituted with an