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Substituted Pyrazolo[3,4-d]pyrimidines: Microwave-Assisted, Solvent-Free Synthesis and Biological Evaluation

✍ Scribed by Ana M. F. Oliveira-Campos; Aravind Sivasubramanian; Lígia M. Rodrigues; Julio A. Seijas; M. Pilar Vázquez-Tato; Francisco Peixoto; Carlos G. Abreu; Honorina Cidade; Ana Elizabete Oliveira; Madalena Pinto

Book ID
102259821
Publisher
John Wiley and Sons
Year
2008
Tongue
German
Weight
252 KB
Volume
91
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

A simple and efficient method has been developed for the synthesis of various pyrazolo[3,4‐d]pyrimidines by using microwave irradiation under solvent‐free conditions. The advantages of applying microwave irradiation compared with the classical method were demonstrated. The structures of all the compounds were confirmed by the usual techniques and, in two cases, by X‐ray analysis. The compounds did not display appreciable ability to inhibit xanthine oxidase activity. Screening for antifungal activity showed that some derivatives were active against four fungi, with more significant results for Botrytis.

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ChemInform Abstract: Substituted Pyrazol
ChemInform Abstract: Substituted Pyrazolo[3,4-d]pyrimidines: Microwave-Assisted, Solvent-Free Synthesis and Biological Evaluation.
✍ Ana M. F. Oliveira-Campos; Aravind Sivasubramanian; Ligia M. Rodrigues; Julio A. 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 27 KB 👁 1 views

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