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Substituted N-(2-aminophenyl)-benzamides, (E)-N-(2-aminophenyl)-acrylamides and their analogues: Novel classes of histone deacetylase inhibitors

✍ Scribed by Oscar Moradei; Silvana Leit; Nancy Zhou; Sylvie Fréchette; Isabelle Paquin; Stéphane Raeppel; Frédéric Gaudette; Giliane Bouchain; Soon H. Woo; Arkadii Vaisburg; Marielle Fournel; Ann Kalita; Aihua Lu; Marie-Claude Trachy-Bourget; Pu T. Yan; Jianhong Liu; Zuomei Li; Jubrail Rahil; A. Robert MacLeod; Jeffrey M. Besterman; Daniel Delorme


Book ID
108074031
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
165 KB
Volume
16
Category
Article
ISSN
0960-894X

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## Abstract HDAC inhibitors induce histone hyperacetylation by a relative increase of histone acetyltransferase activity. Histone hyperacetylation may affect chromatin structure and susceptibility to DNA‐damaging stress, such as IR. We here investigate whether these inhibitors can radiosensitize hu